Tonight on FOX, FBI Agent Seeley Booth of 'Bones' meets Stewie Griffin of 'Family Guy'!
It looks like Booth is having an hallucination, not a full-bore crossover from the Tooniverse. But such a thing is pozz'ble, as shown by Drew Carey (with Daffy Duck) and Jerry Seinfeld (with Superman).
It's a shame too, since we know Stewie can cross over into the live action Toobworld. He and Brian did so during the Emmy Awards a few years back.