There was a 'Pushing Daisies' panel at the Paley Festival this past Saturday night. (All of the cast save for Swoosie Kurtz was there - she had an ailing aunt to attend.)
Several points came up which perfectly fit the concept of televisiology, "thinking inside the box".
1] The show's creator Bryan Fuller doesn't think Ned and Chuck could ever have a child together. "I think her egg would die when his sperm hit it." (Personally, I think she'd die as well.)
2] Fuller also confirmed that Ned the Piemaker is a vegetarian. That's because any meat he ate would probably come back to life one it made contact with his insides. And then it would "crawl out of him". (I would think the vegetables he ate would come back to life as well, but unless he ate Tybo the Giant Carrot from 'Lost In Space', it's not about to crawl out of him.)