At least the last season of 'Roseanne' turned out to be a fantasy growing out of a book that Roseanne was writing after the death of her husband Dan. Considering that in "real life" her sister was gay, and that it was Becky who was really with David and Darlene was the daughter with Mark, then perhaps most of the show was nothing more than a novel.
But the universal power of "The Numbers" from 'Lost' held sway over even this. In the novel, which we saw occur in an episode to kick off the final season of the show, Roseanne and her sister won the lottery - a staggering 108 million dollars.
"108" is the sum total of "The Numbers" - 4, 8, 15, 16, 23, and 42.
The full sequence of "The Numbers" occurred in an episode of 'Veronica Mars' on a fortune cookie message. And "23" was the number of Mohinder Suresh's motel room in Montana on 'Heroes'. "42" has occurred in several different TV shows, like 'The X-Files' (It's Mulder's apartment number), but is best known from 'The Hitch-Hiker's Guide To The Galaxy" as the answer to Life, The Universe, and Everything.