In the 'Monk' episode "Mr. Monk's Favorite Show', Christine Rapp was a former child actress who wrote a tell-all autobiography - for which she was apparently receiving death threats. Adrian Monk suggested that she should check into a motel under an assumed name until the case could be solved.
At the Safari Inn, the desk clerk assigned her a room at the top of the outside stairwell. And the number of that room?
"8" - one of "The Numbers" in the sequence from 'Lost'!